A study published in the Journal of the American Medical Association found that treatment with folic acid plus vitamin B12 was associated with increased cancer outcomes and all-cause mortality in patients with ischemic heart disease in Norway, where there is no folic acid fortification of foods.
So do you throw out the folic acid and B12? Not just yet. Folic Acid and B12 are important B vitamins. I would recommend that if you are a healthy individual without any heart disease, stick to the RDI which is 400mcg per day. Pregnant women should continue to take 800mcg to prevent neural tube defects and spina bifida. And of course, always consult with your doctor or pharmacist before taking large doses of any supplement.